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Breast Implant Boss Arrested



The scandal in the defective, badly created breast implants from French corporation Poly Implant Prothese (PIP) proceeds along with the arrest of Jean-Claude Mas, seventy two, who according to police continues to be held at his household in Six-Fours-les-Plages within the South of France.

Around four hundred,000 thousand women are believed to acquire been granted the implants along with the issue extends throughout some sixty five nations, with England and France among other individuals assuring all those concerned the community wellness process will go over the fee of removing or replacing the implants.

The French banned the implants in 2010, with concerns of attainable ruptures and leaks, just after identifying the maker had not been making use of the accepted materials.

Mr. Mas stayed in his dwelling, though police produced a look of your premises, and he was then used into the countrywide police station in Marseilles. His attorney designed a press release on the AFP news agency:

"He is just not well, he's drained and he is waiting
for his health practitioner."

Even so, Mr. Mas will be unquestionably made to answer for his unscrupulous company techniques, primarily considering that he admitted to police that he instructed workforce at his manufacturing unit to hide the unauthorized silicon from inspectors once they came to the facility.

Also he admitted for the duration of an additional interview that his enterprise PIP had been fooling EU inspectors for some thirteen a long time.

He countered accusations versus him, by proclaiming that the content was properly reliable and blamed the authorities for placing girls with the possibility of unneeded surgical procedures to replace completely useful implants, albeit ones with unapproved product within them.

He also said that he had nothing to say on the victims, and considered they were only generating grievances for monetarily inspired factors. The French Magistrate is reviewing the contents of the job interview with Mr. Mas, and to date some thirty,000 females in France happen to be suggested to interchange their implants.

Across the globe, well being officers have been advising women to hunt replacements. The German, Czech and Venezuelan authorities urged gals to remove their implants, though the British that have some forty,000 impacted women, appear to get Mr. Mas's point of view, stating there was nothing at all to be involved about, except if there were issues with agony or tenderness. Individuals fitted using the implants to the British NHS will probably be presented replacements, and those sufferers who at first had surgical procedures in personal apply will likely be supplied removals to the NHS if theit personal practitioners refuse to eliminate them.

Two non-public companies, Rework as well as Healthcare facility Team from the Uk said which they will eradicate the implants free of charge, but patients is going to be needed to pay for approximately ?one,five hundred to ?two,five hundred for replacements.

Written by Rupert Shepherd
Copyright: 2012


ID 5983
Name Alpha-mannosidase 2
Synonyms
  • EC 3.2.1.114
  • Alpha-mannosidase II
  • Mannosyl- oligosaccharide 1,3-1,6-alpha-mannosidase
  • MAN II
  • Golgi alpha- mannosidase II
  • Mannosidase alpha class 2A member 1
Gene Name MAN2A1
Protein Sequence
>Alpha-mannosidase 2
MKLSRQFTVFGSAIFCVVIFSLYLMLDRGHLDYPRNPRREGSFPQGQLSMLQEKIDHLER
LLAENNEIISNIRDSVINLSESVEDGPKSSQSNFSQGAGSHLLPSQLSLSVDTADCLFAS
QSGSHNSDVQMLDVYSLISFDNPDGGVWKQGFDITYESNEWDTEPLQVFVVPHSHNDPGW
LKTFNDYFRDKTQYIFNNMVLKLKEDSRRKFIWSEISYLSKWWDIIDIQKKDAVKSLIEN
GQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLENNIGVKPRSGWAIDPFGHSPTMAYL
LNRAGLSHMLIQRVHYAVKKHFALHKTLEFFWRQNWDLGSVTDILCHMMPFYSYDIPHTC
GPDPKICCQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRTKVLL
APLGDDFRYCEYTEWDLQFKNYQQLFDYMNSQSKFKVKIQFGTLSDFFDALDKADETQRD
KGQSMFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESHLRAAEILYYFALRQAH
KYKINKFLSSSLYTALTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIG
NSAFLLILKDKLTYDSYSPDTFLEMDLKQKSQDSLPQKNIIRLSAEPRYLVVYNPLEQDR
ISLVSVYVSSPTVQVFSASGKPVEVQVSAVWDTANTISETAYEISFRAHIPPLGLKVYKI
LESASSNSHLADYVLYKNKVEDSGIFTIKNMINTEEGITLENSFVLLRFDQTGLMKQMMT
KEDGKHHEVNVQFSWYGTTIKRDKSGAYLFLPDGNAKPYVYTTPPFVRVTHGRIYSEVTC
FFDHVTHRVRLYHIQGIEGQSVEVSNIVDIRKVYNREIAMKISSDIKSQNRFYTDLNGYQ
IQPRMTLSKLPLQANVYPMTTMAYIQDAKHRLTLLSAQSLGVSSLNSGQIEVIMDRRLMQ
DDNRGLEQGIQDNKITANLFRILLEKRSAVNTEEEKKSVSYPSLLSHITSSLMNHPVIPM
ANKFSSPTLELQGEFSPLQSSLPCDIHLVNLRTIQSKVGNGHSNEAALILHRKGFDCRFS
SKGTGLFCSTTQGKILVQKLLNKFIVESLTPSSLSLMHSPPGTQNISEINLSPMEISTFR
IQLR
Number of Residues 1144
Molecular Weight 131142
Theoretical pI 7.61
GO Classification
Function
hydrolase activity, acting on glycosyl bonds
hydrolase activity, hydrolyzing O-glycosyl compounds
mannosidase activity
catalytic activity
alpha-mannosidase activity
hydrolase activity
Process
monosaccharide metabolism
hexose metabolism
mannose metabolism
physiological process
metabolism
cellular metabolism
macromolecule metabolism
carbohydrate metabolism
alcohol metabolism
General Function Carbohydrate transport and metabolism
Specific Function Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway
Pathways Not Available
Reactions Not Available
Pfam Domain Function
Signals None
Transmembrane Regions 6-26
Essentiality Non-Essential
GenBank Protein ID Not Available
UniProtKB ID Q16706 Link_out
UniProtKB Entry Name MA2A1_HUMAN Link_out
PDB ID Not Available
Cellular Location Golgi apparatus membrane
Gene Sequence Not Available
GenBank Gene ID D63998 Link_out
GeneCard ID Not Available
GenAtlas ID MAN2A1 Link_out
HGNC ID HGNC:6824 Link_out
HPRD ID Not Available
IUPHAR ID Not Available
Guide to Pharmacology ID Not Available
Chromosome Location Not Available
Locus Not Available
SNPs MAN2A1 Link_out
General References
  1. Misago M, Liao YF, Kudo S, Eto S, Mattei MG, Moremen KW, Fukuda MN: Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme. Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11766-70. Pubmed
Drugs
DrugBank ID Drug Name Drug Type Drug Groups
1 DB06984 (1R,2R,3R,4S,5R)-4-(BENZYLAMINO)-5-(METHYLTHIO)CYCLOPENTANE-1,2,3-TRIOL small molecule experimental
2 DB08321 (1S,2S,3R,6R)-4-(hydroxymethyl)-6-(octylamino)cyclohex-4-ene-1,2,3-triol small molecule experimental
3 DB03955 1,5-Dideoxy-1,5-Imino-D-Mannitol small molecule experimental
4 DB02318 2-Deoxy-2-Fluoro-Alpha-D-Mannosyl Fluoride small molecule experimental
5 DB03008 5-Fluoro-Beta-L-Gulosyl Fluoride small molecule experimental
6 DB03414 5-Thio-a/B-D-Mannopyranosylamine small molecule experimental
7 DB02492 Ghavamiol small molecule experimental
8 DB02742 Kifunensine small molecule experimental
9 DB02034 Swainsonine small molecule experimental

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